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A recent study revealed that TDP-43 accumulation within stress granules, together with oxidative stress, collectively induces intra-condensate demixing, leading to a TDP-43-enriched phase that forms pathological cytoplasmic aggregates (Yan et al., 2025)

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However, free radicals also have indispensable physiological functions (e.g., acting as signaling molecules and regulating immune responses), and their deficiency may lead to health complications (Valko et al., 2007)

Repeated cocaine administration attenuates group I metabotropic glutamate receptor-mediated glutamate release and behavioral activation: a potential role for Homer 1b/c