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The 1973 isolation, the 1988 collagen stimulation paper, the 2018 gene-data review, and the 2015 microneedle delivery paper form a continuous arc that is unusually well-supported for a cosmetic active

This leads to increased systemic ROS, which can contribute to cardiovascular events and promote atherosclerosis

doi: 10.1042/BSR20180541 16 HaoLWanYXiaoJTangQDengHChenL

From a molecular point of view, decreased GSH levels, which can occur as a consequence of GS-HgCH 3 complex formation, will cause increased reactive species (H 2 O 2 , nitric oxide, etc.) generation and oxidative damage in a plethora of biomolecules (nucleic acids, lipids and proteins)

Fehniger 2000

10.1186/s12888-021-03428-3 69 MadihaS.HaiderS