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Overproduction of free radicals such as reactive oxygen species and reactive nitrogen species leads to oxidative stress, which is associated with the pathophysiology of various human diseases including cancer, cardiovascular disease, atherosclerosis, hypertension, ischemia/reperfusion injury, diabetes mellitus, neurodegenerative diseases (Alzheimer disease and Parkinson disease), rheumatoid arthritis, and ageing

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Also, autaptic hippocampal cultures produced from these transgenic mice showed a decrease in both amplitude and frequency of EPSCs, whilst neurons of Mecp2 Tg1 mice, with an upregulated Mecp2 gene, had an opposite effect [377]