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Yang K, Fan M, Wang X, Xu J, Wang Y, Gill PS, et al

[1] [2] Increasing levels of CD38, a membrane-bound NADase that destroys both NAD+ and its precursor nicotinamide mononucleotide, are thought to be the cause of the age-related decline in NAD+ levels, according to a 2016 study in mice, which exhibit age-related declines in NAD+ levels similar to those seen in humans

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CD44 mediates iron endocytosis enabling iron-mediated epigenetic plasticity 74 , and a variant of CD44 interacts with and stabilizes the glutamate-cystine antiporter Xc, thereby maintaining glutathione synthesis 75