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[DOI] [PMC free article] [PubMed] [Google Scholar] 6.Matsumoto K et al

10mL or more should be split and given at successive intramuscular and subcutaneous sites

in NP-MSCs, the combined effect of hypoxia and nutrient deprivation inhibits cell proliferation, induces apoptosis, enhances caspase-3 activity, and downregulates functional genes (e.g., proteoglycan, collagen-I and -II) and stem cell-related genes (including Oct4, Nanog, Jagged, and Notch1) (Tian et al., 2020)