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LION -formulated repRNA offers significant advantages over other RNA vaccine platforms, including limiting the dissemination of RNA to the injection site which induces antigen-specific adaptive immunity while avoiding systemic inflammation 37

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10.1007/s10787-017-0358-8 12 Berkopic CesarL.GojkovicS.KrezicI.MalekinusicD.ZizekH.Batelja VuleticL.et al (2020)

Ca 2+ also activates the cysteine protease calpain-1, which degrades cytoskeletal proteins such as the ankyrin-R complex, promoting membrane blebbing and increasing cellular adhesiveness (Restivo et al., 2021)

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