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PMID: 36129147

Mitochondria contain multiple copies of their own genome, mitochondrial DNA (mtDNA), which encodes for 13 polypeptides of the OXPHOS and respiratory chain, as well as two ribosomal RNAs and 22 transfer RNAs necessary for translation of polypeptides inside mitochondria

This event may represent a possible mechanism by which myelin phagocytosis results in a pro-inflammatory response and would explain the acquisition of the inflammatory role of microglia in later stages of the lesion

& Ohm, J

Notably, previous studies have confirmed that the aforementioned gut bacteria regulated by dietary fiber (e.g., Bifidobacterium, Lactobacillus, Faecalibacterium ) are closely associated with depression ( 5.3 Potential mechanisms of dietary fiber affecting depression (1) Mood regulation mediated by SCFAs produced via gut microbiota fermentation Dietary fiber cannot be digested and absorbed by the human body but can be partially or fully fermented by gut microbiota (122)

797 Even neonatal rat ventricular muscle cells with low sensitivity to GPX4 inhibition underwent ferroptosis in the presence of cysteine deprivation, suggesting that inhibition of GPX4 promotes ferroptosis of cardiomyocytes under metabolic stress, such as cysteine deprivation