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Replication stress is a key driver of functional decline in aged HSCs, which is due to reduced expression of mini-chromosome maintenance genes and impaired DNA replication dynamics

Two were NOT APPROVED because they contained less than the expected 1,3:1,6-beta-D-glucan a biologically active compound

Reported Phe-loop mutations had very different effects on NS3h activity in vitro, ranging from abrogated helicase activity while maintaining ATPase activity (F438A), abrogated helicase and ATPase activity (F444A, both 78 ) or reduced helicase activity (F438L 79 )

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Disadvantages are low bioavailability, poor stability, and obvious sulfur odor

Similarly, the depletion of cholesterol in the membrane lipid raft leads to the collapse of the H gradient and the acceleration of LMP progression [29, 30]