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Assessments The primary efficacy endpoint was SVR, defined as undetectable HCV RNA 12 weeks after the end of treatment (SVR12)

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The use according to Claim 37, wherein said at least three different compounds are Naltrexone, Tetrathiomolybdate, and Metformin

This occurs because high intensity stimulation generates a larger pool of active and dephosphorylated PKC, thus providing enough time for degradation pathways to interact with PKC and target it for down-regulation (Figure 6D: No HSP-60 overexpression case)