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The variations in the signal (s) region and in the mid (m) greatly influence the effects of VacA, especially the s region variation which is associated with the vacuolating activity of VacA, whereas the m region of VacA determines the cell specificity of vacuolation by affecting the binding of VacA to the host cells

Yan L, Xie M, Lu H, Zhang H, Shi M, Zhang Y et al (2018) Anti-apoptotic effect of IGF1 on Schwann exposed to hyperglycemia is mediated by neuritin, a novel neurotrophic factor