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10.1111/j.1748-5827.1975.tb05773.x 99

Therefore, guidelines emphasize the need to exclude other crystal-induced arthropathies (e.g., pseudogout) and consider the diagnosis in conjunction with typical symptoms such as joint swelling, redness, heat, and pain (Panlu et al., 2024

Introduction Amodiaquine is a potent anti-malaria drug, however, rare but life-threatening idiosyncratic hepatotoxicity (1/15,500 patients) and agranulocytosis (1/2000 patients) have restricted its therapeutic use (Walgren et al., 2005)

The Recycling Connection There is an even deeper connection between the two

Therefore, a workshop was organized by EURL ECVAM to investigate whether the in vitro mammalian cell genotoxicity test results could complement and mitigate the implications of a positive Ames test response for the prediction of in vivo genotoxicity and carcinogenicity, and if patterns of results could be identified (see workshop report Kirkland et al., 2014a)