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For many metabolites, their serum levels are highly heritable, the biological characteristics of metabolites detected in human biological fluids bridge the gap between genotype, environment, and phenotype, and can serve as biomarkers for clinical diagnosis, prognosis, and disease classification [15, 16]

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We aim to demonstrate that the antioxidant and anti-inflammatory properties of bilirubin can protect dopaminergic neurons and delay the onset of Parkinson's disease