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Finally, the main issues for future revisions are presented as Future Research Questions

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1 Introduction Osteosarcoma (OS), a highly aggressive malignancy predominantly affecting adolescents, continues to pose significant clinical challenges due to its elevated mortality rate and propensity for recurrence and metastasis despite advancements in multimodal therapies ( Emerging as a distinct form of regulated cell death, ferroptosis diverges fundamentally from apoptosis in its biochemical execution ( + /Fe + -mediated Fenton reactions that catalyze hydrogen peroxide (H 2 O 2 ) decomposition ( Against this backdrop, Rhizoma Paridis, a traditional Chinese medicinal herb, and its major bioactive components, Rhizoma Paridis total saponins (RPTS), have attracted attention for their potent antitumor activities

With less of this substance being produced as the body ages, L-glutathione counteracts the damaging effects of free radicals, helping to slow the aging process and prevent degenerative diseases

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