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Description

Retatrutide is a relatively large molecule, and aggressive reconstitution can denature portions of it, reducing potency

R Chesworth, D Cheng, C Staub, T Karl

10.1111/jcmm.13930 22 FengX.SuredaA.JafariS.MemarianiZ.TewariD.AnnunziataG.et al (2019)

Functionally, cagrilintide activates amylin receptors AMY1R, AMY2R, AMY3R and the calcitonin receptor (CTR), binding via a conserved bypass motif involving mid-segment residues (S19 P25) (Cao et al