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It's worth noting that metformin, commonly used for diabetes, is actually associated with reduced B12 levels rather than elevation

HMGB1, a ligand of TLR4, can shuttle between the nucleus and cytoplasm

[58] Digoxin, HSP90 inhibitor 17-DMAG (alvespimycin), and navitoclax, among other senolytic agents, have been shown to significantly decrease atherosclerotic lesion formation and plaque burden in ApoE -/- mice of atherosclerosis

Lots of people do take B-12 supplements