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(A-B) Immunofluorescence staining and quantitative analysis of TUNEL (green) staining of skin tissues from each group

Inhibition of cysteine-glutamate transporter protein system (e.g., Erastin) will deplete intracellular GSH, eventually resulting in the inactivation of GPx4 and the accumulation of lipid peroxidation, which can induce cell ferroptosis to a certain extent [75]

In order to be successfully synthesized in ER, the chaperone GRP78 is induced and activated to promote the refolding process of misfolded proteins (Yoboue et al., 2017) , (Wei et al., 2012)

Use once or twice daily for best results, especially in the morning and evening

doi: 10.1038/s41573-019-0054-z 79 BarabFGilbertCLiaoNBourgoinSGNaccachePH

Nature 493 , 542546 (2013)