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Although silencing the gene UL39 can limit the proliferation of oncolytic HSV-1 after injection, enhancing the safety of this oncolytic virus in clinical applications, the tumor-killing effect of this oncolytic virus is also restricted, requiring a larger dosage and multiple injections to achieve the desired effect

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This approach enhances the likelihood of the glucose being effectively used to produce ATP thereby helping to prevent the hastening of cell damage or death, in brain structures

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