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The suggested peptide, which has the sequence RER-EtBn, has the ability to stimulate the phosphorylation of its major target, AKT serine, inhibit the phosphorylation of Gsk-3, and then promote the translocation of the GLUT4 protein to the cell membranes surface to promote glucose translocation, all of which have a positive impact on the state of insulin-resistant glucose metabolism ( It is evident that LF ameliorates hepatic insulin resistance and pancreatic dysfunction in T2DM mice by regulating the PI3K/AKT signaling pathway