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Consequently, the healing of perforated defect by a cytoprotective agent (intended reversal of damaged tissue to normal structure (29) that BPC 157 application consistently exerts (10, 11, 21-25, 38), unlike standard cytoprotective agents, effective administration before but not after noxious agent) (29-34, 39-45)) conceptually goes as a prototype of the direct beneficial effect (35-37), and cytoprotection agents efficacy in fistulas healing (1, 19, 20)

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[DOI] [PubMed] [Google Scholar] 38.Barrientos S, Brem H, Stojadinovic O, Tomic-Canic M

A clinical trial (NCT01332721) combining an anti-CD105 (TRC105), and Bevacizumab has shown a good tolerance and clinical activity in adults with advanced cancer