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Aging Cell 13, 631640

The library was screened against TNBC cells by incubating the membrane with different cells followed by labeling the bound cells with a fluorescent dye

Impaired platelet activation and cAMP homeostasis in MRP4-deficient mice

A-D , Individual antibodies against specific modifications can be used to reveal the localization of histone modifications within the nucleus and suggest colocalization ( A-C ) or not ( D )

[0312] Additionally chimeric constructs are provided that expand beyond targeted chemotherapy to immunotherapy by incorporating, for example, providing bispecific antibodies comprising an anti-ALPP/ALPPL2 antibody attached to a second antibody that is capable of recruiting and activating immune system components or attached to a moiety that is a checkpoint inhibitor {e.g., anti- CTLA4 {e.g., comprising an ipilimumab variable region), and/or antibodies directed against PD-L1 {e.g., comprising an nivolumab, or pembrolizumab variable region), and/or antibodies directed against PD-L2