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The persistence of symptoms despite TNF inhibition suggests that effective intervention requires a multi-target approach addressing epithelial stability and ROS signaling rather than inflammation alone

Stem cell metabolism in tissue development and aging

First, ferroptosis shapes the TME in ways that promote immune suppression and tumor progression

J Cutan Pathol (1993) 20(3):193202

Wang F, Li W-l, Shen L-j, Jiang T-t, Xia J-j, You D-l, et al

Initial versions relied on serum cytokine levels [ , ] and further modifications used duration of vasopressor support and oxygen (FIO 2 ) requirements as criteria for CRS severity []