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Although some FAO inhibitors, such as etomoxir, have shown great potential in preclinical experiments, their clinical transformation has been hampered by high toxicity, dose tolerance and poor specificity [206]

Animal studies have shown that mice with Med23 mutations exhibit hypomyelination and cognitive impairments

155, no

Marras C, Lang AE, Oakes D, McDermott MP, Kieburtz K, Shoulson I, et al

Vitamin B12 deficiency can potentially cause severe and irreversible damage, especially to the brain and nervous system

Body Weight Changes Animals in the control group had a consistent increase in body weight with values at day 21 (166 12.1g) being 19.4% higher than initial body weights (139 6.4g) (Table 1)