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1 Introduction Cardiovascular disease (CVD) remains the leading cause of mortality globally, with approximately seven million deaths in 2020, representing 12.8% of all deaths (Virani et al., 2020

By altering the mechanism of ROS via inhibiting or minimizing oxidative stress, the insights on animal models presented in this study offer future perspectives on the potential biomarkers and therapeutic options

N.et al (2006)

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3-HK directly binds NCOA4 and blocks ferritinophagy initiation To further elucidate how 3-HK modulates ferritinophagy, we investigated its impact on the interaction between NCOA4 and FTH1, an essential step initiating ferritinophagy 12