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Single-nuclei transcriptomes from sALS and C9orf72 ALS revealed that C9orf72 hexanucleotide repeat expansion impairs the microglial cell state transition to activated state compared to sALS (Masrori et al., 2025)

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doi: 10.34172/apb.44060 301 FangJWuQYeFCaiCXuLGuYet al

Intermittent and low-level inhibition of key UPS components, which triggered only very mild stress in the differentiating hMSCs, had surprisingly distinct effects on the bone-like material they formed, altering its stiffness and the amount of protein and crystalline mineral it contains, and affecting its micro- and ultra-structural organization (53)