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Baseline clinical data included stroke type, aetiology, risk factors, demographic and socioeconomic information

Prophylactic administration of memantine at a low dosage of 0.2 mg/kg significantly decreased infarct size with improved behavioral outcomes, but administration of higher doses of memantine (2-10 mg/kg) was counterproductive and potentiated ischemic injury in mice 86

So far, paracetamol 750 mg/kg per os (6) induced brain edema in rats but no behavioral changes

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It may be helpful to walk through the changes in the molecule as we proceed from extremely low pH to high pH