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Humoral immunity involves autoreactive B cells and plasma cells that produce high-affinity antibodies against Tg and TPO, furthering tissue injury through complement activation and antibody-dependent cell-mediated cytotoxicity (ADCC)

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Even determining which form of the peptides should be used was unclear to regulators

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Because these medications are processed through different metabolic routes, they are unlikely to directly interfere with each other's breakdown or elimination from the body