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A deeper understanding of these interconnected pathophysiologic mechanisms will facilitate the development of targeted therapies beyond cysteamine, optimizing treatment approaches to mitigate disease progression [146]

As we age and NAD+ levels drop, sirtuins become less active, which speeds up aging [10]

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3.4 Intervention in mitochondrial energy metabolism Micronutrients like Cu make vital impacts on mitochondrial function, particularly in mitochondrial-rich tissues like cardiac muscles (Tian et al., 2023)

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