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Common conditions treated with trigger point injections include fibromyalgia, tension headache, and myofascial pain syndrome

12,13,14,15 The principal Cu chaperones include COX17 (which delivers Cu to cytochrome c oxygenase), CCS (Cu chaperone for superoxide dismutase, which delivers Cu to superoxide dismutase 1), and ATOX1 (which delivers Cu to ATP7A and ATP7B)

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Targeting oxidative stress in disease: promise and limitations of antioxidant therapy

According to the equation, when the denominator (plasma concentration) is very small relative to the numerator (total amount of drug in the body), the resulting Vd must be very large to maintain the mathematical relationship

Subsequent copper binding induces aberrant oligomerization of these proteins, disrupting the TCA cycle and initiating cell death [55]