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It is unlikely that the observed mitochondrial lesions are irrelevant to the longer-term functioning of a cell or cell network, but it is not clear if the observed mitochondrial dysfunction observed shortly after exposure is cleared or persists long-term

Zhu J, Wang Z, Tao L, Han L, Huang Q, Fang X, Yang K, Huang G, Zheng Z, Yawalkar N, Zhang Z, Yan K (2022) MTHFR Gene Polymorphism Association with psoriatic arthritis risk and the efficacy and hepatotoxicity of methotrexate in psoriasis

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