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Even less information exists regarding the role of Se in these processes

It not only has antioxidant effects but also increases NRF2 levels, clears peroxynitrite, inhibits Fe 2 transport, and binds to protein thiol groups [430]

SUMOylation of GPX4 Might Mediate Lipid Peroxidation Inhibition In addition to phosphorylation and glycosylation, SUMOylation is also predicted to occur on GPX4

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Therefore, future strategies should implement molecular switches or shorter half-life constructs CARs that express transiently or degrade after a specific period to reduce long-term immune suppression

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