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1 Introduction It is well recognized that various infectious diseases can generate dysfunction in the hypothalamus and/or pituitary gland, affecting its normal functioning ( The vulnerability of the adenohypophysis to infection by intracellular pathogens is largely due to the lack of an effective blood-brain barrier in the pituitary ( Cortisol exerts several innate and adaptive immunosuppressive effects

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Further support comes from the Helmholtz Association under the Helmholtz Young Investigator Group Programme, [VH-NG-128 to M.M.] and the European Research Council (ERC) [ERC-StG COVIDecode, 101040914 to M.M.]

Quickly taken up by the erythrocytes where they (in particular, dapsone monohydroxylamine) are primarily responsible for the hematologic adverse effects of methemoglobinemia and hemolysis

F.PetrucelliL.BurattiE.et al

10.1002/anie.201106527 7 BestM