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Nrf2 depletion can increase the susceptibility to infection and inflammatory diseases due to impaired cellular stress response and exacerbated immune-mediated hypersensitivity and autoimmunity [61]

This suggests that CDCZA exhibited potent cytotoxicity against tumor cells

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These observations suggest that the effect on the expression level of the target gene may be correlated with the presence or absence of SMARCA4 protein expression rather than with the expression level or mutation of the SMARCA4