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Targeting epiregulin in the treatment-damaged tumor microenvironment restrains therapeutic resistance

Mediated uptake of ferritin-bound iron by TfTfR1

The route of administration could be intravenous or subcutaneous, factors determined by the peptides stability and bioavailability requirements

Immune infiltrates in ectopic lesions include increased macrophages, mast cells, and memory CD4+ T cells, alongside decreased NK cells and plasma cells, mirroring autoimmune pathologies ( 2.2.4 Chronic inflammatory milieu Pro-inflammatory cytokines (TNF-, IL-6, IL-1, IL-8, IL-17) and chemokines (RANTES) accumulate in peritoneal and follicular fluid, creating a hostile microenvironment

Gattazzo F, Urciuolo A, Bonaldo P

Pathobiology of pulmonary fibrosis