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The results revealed that EX527 reversed the decrease of catenin acetylation and ubiquitination in CRIP1knockdown cells treated with mildronate (Fig 6I), while the levels of carnitine and acetylcarnitine were not affected (Appendix Fig S6H), indicating that the decrease of catenin acetylation via CRIP1mediated acetylcarnitine downregulation prevented its ubiquitination and proteasomal degradation

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