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Trends in Pharmacological Sciences 32:300-307

Graphical Abstract Access this article Similar content being viewed by others Data Availability Not applicable

As a control, normal RBCs (nRBC) were vehicle-treated and incubated under identical conditions

However, more in-depth studies are necessary to elaborate the mechanism of the bioactive secondary metabolites on different stages of the immune response

interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-), IB is phosphorylated at Ser32 and Ser36, resulting in the rapid ubiquitination by the proteosome in the dependent manner to release NF-B [5, 6]