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SEPAHAN study

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Mishima, Y

Another critical aspect of these studies is that none of such results were derived directly from iLBD cases, and, although it is conceivable that, for instance, oligomeric non-aggregated Syn species affect synaptic function prior to the appearance of typical LBs, the specific significance of such Syn species remains uncertain

In AD and other tauopathies, these chaperones modulate tau homeostasis by preventing aggregation of hyperphosphorylated tau species and promoting their degradation

& Munro, S