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These partially reduced species of oxygen are highly reactive and have a very short half-life

Consequently, regulating GzmB through Sb9 could represent a novel therapeutic strategy for preventing cardiovascular diseases, such as atherosclerosis, plaque rupture, and ventricular remodeling after acute myocardial infarction (AMI) (134)

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Chem Phys Lipids 157:111 Devasagayam T, Boloor K, Ramasarma T (2003) Methods for estimating lipid peroxidation: an analysis of merits and demerits

It has also been shown that KEAP1 is a negative regulator of NF-B signaling via inhibition of IKK- phosphorylation and by mediating IKK- degradation by autophagocytosis (80)