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The passage of pyruvate therefore occurs through specific transporters, the mitochondrial pyruvate carriers (MPC), a hetero-oligomeric complex of two subunits, indicated as MPC1 and MPC2

Like all enzymes, phosphoglycerate kinase can catalyze the reaction in both directions

J Clin Biochem Nutr (2015) 56:17

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Therefore, we proposed that the decrease in GPx1 caused by glucose deprivation leads to further ROS-dependent autophagy activation

The PPP converts glucose-6-phosphate to pentose and produces ribose-5-phosphate and NADPH