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The complexity of bioactive compounds in medicinal plants, variability in preparation processes, and the unpredictability of their absorption, distribution, metabolism, and excretion in the body collectively constitute the primary translational bottlenecks

The architecture is highly similar to the recently reported CENP-A/H4 octasome (29) and parallels earlier 2(H3/H4) 2 H3H4 octasomes observed by cryo-EM and in-cell cross-linking (28)

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We observed that other exogenous large protein and oligosaccharide antigens were also rapidly transferred to the parenchyma of draining LNs via the same mechanism