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There are various potential causes of vitamin B12 deficiency besides pernicious anemia, which gastrointestinal surgery long-term use of certain medications, such as proton pump inhibitors genetic intrinsic factor defects dietary deficiency Pernicious anemia requires lifelong treatment

Patients with ALK -rearranged NSCLC, which mostly occurs in individuals who have never smoked, are younger on average at diagnosis (median age at diagnosis 5052 years) 1922 , as are patients with other LUADs harbouring oncogenic fusions, for example, involving RET 23,24 , ROS1 (refs

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But here's where I pause: all of this is in rodents