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Some literature describes PT-141-mediated nitric oxide release as a secondary pathway contributing to smooth muscle relaxation in erectile tissue but this is considered a downstream consequence of central neural activation rather than a primary mechanism

BMC Cancer 8:122

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"Detox: Methylation

Pre-treatment with TPA induced neurite outgrowth and growth cone formation, which was blocked by the selective inhibitors, suggesting the selective involvement of Protein kinase C alpha (PKC) (Choe et al., 2002)