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SVCT1 is found mostly in epithelial tissues (e.g., small intestine and proximal tubule of the nephron), where the transport of ascorbate is greater than that required by the cells

doi: 10.1016/s0278-5846(96)00103-0

This allowed a variety of boronic acids to be coupled to a model cysteine-linked aryl iodide, with the benefit that even hydrophobic moieties could be transferred to the protein surface due to the water-solubilizing effect of the boronate group

Further trials should conduct better randomization and blinding procedures, recruit more participants, and provide adequate reporting

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However, preclinical studies have highlighted several critical safety concerns, particularly regarding cell retention, biodistribution, and oncogenic risk