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Blood (2013) 122:284

Distribution then occurs rapidly throughout the cortex, hypothalamus, and other brain regions

The blue colour indicates active peptide

GDNF has a strong neuroprotective profile and is being actively explored for the treatment of neurodegenerative diseases, particularly gene therapy approaches for PD (Kakoty et al., 2024

TB-500 promotes actin polymerization essential for keratinocyte migration

Research indicates that low maternal B12 status is associated with a higher risk of adverse outcomes, including neural tube defects, preterm birth, low birth weight and potential impacts on cognitive development, although evidence of direct causation remains limited