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The 40-item ALS Assessment Questionnaire (ALSAQ-40) has also been used frequently in trials, measuring five domains (eating and drinking, communication, activities of daily living/independence, physical mobility, and emotional reactions) with strong internal reliability, construct validity, and correlations with ALSFRS-R [60]

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The development of procaine in 1904 did not solve the problem of systemic toxicity, and the Committee for the Study of Toxic Effects of Local Anesthetics published a report of 43 fatal cases linked to the use of LAs