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Of these, rhizopodophyllin has been reported to play an important role in regulating melanogenesis [103]

Tambin estimula la produccin de proteoglicanos (decorina, biglicano) y glicosaminoglicanos, que contribuyen a la hidratacin y elasticidad de la dermis

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How it works for skin: It reduces melanin transfer to skin cells and strengthens barrier function

Specifically, we show that AR directly represses BCL-2 transcription via binding to multiple ARBS across the BCL-2 genomic region, especially the ARBS1 around the promoter, and castration and ARPI treatment block AR engagement to most ARBS leading to de-repression of BCL-2 transcription

Poole, A