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The E510Q mutation, which changes the glutamic acid residue at position 510 to glutamine, accounts for nearly 90% of mutant alleles in Europeans

115,116 In a study of 50 women receiving TSH-suppressive L-T4 therapy, treatment with 2 or 4 g/day L-carnitine was shown to improve clinical and biochemical markers of hyperthyroidism relative to placebo

doi: 10.1073/pnas.0904489106 39 CosolaC.RocchettiM

Given a ~1hour half-life and hourslong systemic presence, a oncedaily or everyotherday regimen during any initial phase is typically pharmacokinetically reasonable

Mild nausea or stomach upset (rare)