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Furthermore, unregulated status of zinc leads to oxidative stress, cell cycle progression, damage of DNA, and angiogenesis, finally resulting in hepatocarcinogenesis (71)

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Chronic hyperglycemia results in the suppressed activity of mTOR associated with AMP-activated protein kinase-induced increase in ROS formation and enhanced expression of thioredoxin interacting protein (TXNIP) a potential sensor of glucose and oxidative stress (Akpoveso et al

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Skin Pharmacol Appl Skin Physiol 14:203209 Hikima T, Yamada K, Kimura T, Maibach HI, Tojo K (2002) Comparison of skin distribution of hydrolytic activity for bioconversion of -estradiol 17-acetate between man and several animals in vitro