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At low JA-Ile levels, the transcription of JA-responsive genes is repressed because of the accumulation of JAZ proteins, but this repressed state is de-repressed by JA-Ile levels elevated in response to environmental and developmental cues, which promote the binding of JA-Ile with JAZ in the COI1 coreceptor and initiate ubiquitination and the subsequent degradation of JAZ by proteasomes

For men who spend significant time outdoors or in urban environments, this protection is essential in preventing premature aging, such as wrinkles and fine lines

Wang J, Wang K, Wang Y, Lin S, Zhao P, Jones G

The limited number of empirical studies available for analysis restricts the explanatory power of the research results