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Animal studies and observations in acromegalic patients demonstrate that GH-excess can have deleterious effects on kidney health, including glomerular hyperfiltration, renal hypertrophy, and glomerulosclerosis

In this context, Everolimus is a promising second-generation rapamycin derivative and is a specific inhibitor of mTORC1, which suppress mRNA translation, ribosome biogenesis, protein synthesis, mitochondrial metabolism, and adipogenesis 83

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It is important to mention that although the elderly group receives a small dose of CoQ10, it is administered in conjunction with transcutaneous electrical acupoint stimulation ( In vitro studies have demonstrated that the addition of 50 M CoQ10 to the culture medium resulted in increased expression of Bcl2 and Sirt1 in cumulus cells, and a positive impact on the reduction of ROS, maturation rate, and first polar body extrusion was enhanced from 48.9% to 75.7% by the addition of CoQ10 to the culture medium (Figure 1)