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The challenge involves reduced appetite making it harder to consume enough of any food

"Exploring the Impact of Cigarette Smoke Extracts on Vitamin B 12 : Insights into the Transformation of Methylcobalamin and Hydroxycobalamin to Cyanocobalamin through In Vitro Evaluation"

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However, it is not known whether vitamin B 12 supplementation, in addition to folic acid supplementation, may be beneficial in the prevention of NTD (62) randomized controlled trials are needed to address this question

The studies summarized below are predominantly preclinical and should be interpreted accordingly